Non-conventional hormone therapy - Tissue-specific Tibolone-Caution

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ORIGINAL ARTICLE

Year : 2010 \| Volume : 1 \| Issue : 2 \| Page : 59-62

Non-conventional hormone therapy - Tissue-specific Tibolone-Caution Jyotsna Potdar Diploma Gynecologic Endoscopic Surgery Keil, Germany, Correspondence Address: Jyotsna Potdar 26 Panmala, 'Potdar Hospital', Sinhagad Road, Pune, Maharashtra, India DOI: 10.4103/0976-7800.76213 PMID: 21716774

Objectives: The present retrospective study was undertaken to assess safety profile of long term Tibolone therapy when one of my patients developed carcinoma breast. Methods: Fifty patients who were put on Tibolone were studied as regards the indication for Tibolone therapy, age distribution, duration of therapy and side effects. Results: Although most subjects responded well to therapy without significant side effects two patients developed breast lump. One of the breast lumps was malignant, the other benign. It is possible that prolonged Tibolone therapy may have caused carcinoma breast as against the notion that Tibolone is breast protective. Few of recent studies like Million Women Study and LIBERATE study which was concluded in April 2010, have shown that Tibolone also increases risk of carcinoma breast. Conclusion: Tibolone when used for management of menopausal symptoms should be given for less than 4 years and regular follow up with mammography is must.



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