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BOOK REVIEW
Year : 2010  |  Volume : 1  |  Issue : 2  |  Page : 96  

Reproductive endocrinology: A molecular approach


Medical Research Center- Kasturba Health Society, Vile Parle West, Mumbai, India

Date of Web Publication28-Jan-2011

Correspondence Address:
Jayashree V Joshi
Medical Research Center- Kasturba Health Society, Vile Parle West, Mumbai
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Joshi JV. Reproductive endocrinology: A molecular approach. J Mid-life Health 2010;1:96

How to cite this URL:
Joshi JV. Reproductive endocrinology: A molecular approach. J Mid-life Health [serial online] 2010 [cited 2019 Nov 22];1:96. Available from: http://www.jmidlifehealth.org/text.asp?2010/1/2/96/76224

Editor- Pedro J Chedrese, Springer, 2009, ISBN 978-0387-88185-0


This piece of work is a brilliant example of molecular endocrinology made amazingly simple. Most clinicians or novel entrants into research are overawed by the intricacies and complexities in biochemical processes that govern life and reproduction in particular. This editor, with his team of authors has succeeded in defining the current frontline knowledge in this area in a lucid and simple manner. The explanations are remarkably simple with beautiful line diagrams when required. The understanding of molecular biology is essential not only for the researchers but has become a necessity for clinicians also in order to understand the new concepts in endocrine diseases. This forms the basis of rational therapeutics and therefore is no longer limited to researchers. This book therefore can fill in the gap in the understanding of new concepts of causation, diagnosis and therapeutics based on fundamentals derived from molecular approaches.

The book is organized in four parts, the first part explains the basic concepts in protein chemistry and molecular biology relevant to the reproductive system. In the second part the techniques are described in brief without the nitty-gritty. The third part deals with the molecular regulation of reproductive hormones. The physiological role of various macromolecules in steroidogenesis, receptor groups, gene therapy, and insights into the function of leptin and neurosteroids have been given. The last part deals with some common abnormalities in reproductive processes such as ovarian failure, androgen disorders and failure of spermatogenesis and novel applications like gene therapy for leiomyoma.

The individual chapters, 27 in number, are crisp and short and make easy reading. Many new advances are summarized in brief. All the signaling systems, endocrine, paracrine, neurocrine, autocrine, juxtacrine, intracrine, cryptocrine, and pherocrine and photocrine are covered.

Another plus point is the resource information on various databases and gene libraries which will be of interest to those involved in serious research. At the end of each chapter the contact address of the contributor and e-mail ID, in the majority of cases, are listed for access to the individual authors. The glossary of new terms and expansion of acronyms used in each chapter are useful for quick reference.

The book is commendable for its brevity, clarity and simplicity despite the complex nature of the main subject. The few drawbacks are that some of the clinical correlates of some diseases or the role of molecular endocrinology in the transitional periods like menarche, lactation or menopause are lacking. Appendix B appears to be a repetition of the information given at the end of each chapter.

In summary it is a commendable addition to any academic institution with students and practitioners of endocrinology. The new molecular basis of physiology, pathology and therapeutics is essential for any professional, whether in basic health sciences or in clinical medicine.




 

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